2-Propanone, 1-(3-methoxyphenyl)-
3-Methoxyphenylacetone
CAS: 3027-13-2
Molecular Formula: C10H12O2
2-Propanone, 1-(3-methoxyphenyl)- - Names and Identifiers
| Name | 3-Methoxyphenylacetone |
| Synonyms | 3-METHOXYPHENYLACETONE 3-Methoxyphenylacetone M-METHOXYPHENYL ACETONE 1-(3-METHOXYPHENYL)ACETONE 3-methoxyphenylpropan-2-one 3-METHOXYBENZYL METHYL KETONE Methyl(3-methoxybenzyl) ketone 1-(3-methoxyphenyl)propan-2-one 1-(3-Methoxyphenyl)-2-propanone 2-Propanone, 1-(3-methoxyphenyl)- |
| CAS | 3027-13-2 |
| EINECS | 221-191-9 |
| InChI | InChI=1/C10H12O2/c1-8(11)6-9-4-3-5-10(7-9)12-2/h3-5,7H,6H2,1-2H3 |
2-Propanone, 1-(3-methoxyphenyl)- - Physico-chemical Properties
| Molecular Formula | C10H12O2 |
| Molar Mass | 164.2 |
| Density | 1.911 g/mL at 25 °C (lit.) |
| Melting Point | 258 °C |
| Boling Point | 258-260 °C (lit.) |
| Flash Point | >230°F |
| Solubility | Miscible with dimethyl sulfoxide. |
| Vapor Presure | 0.0133mmHg at 25°C |
| BRN | 2044357 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.5252(lit.) |
| MDL | MFCD00008771 |
2-Propanone, 1-(3-methoxyphenyl)- - Risk and Safety
| Safety Description | S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
2-Propanone, 1-(3-methoxyphenyl)- - Reference Information
| Application | 3-methoxyphenylacetone can be used for the synthesis of fragrances and also for the synthesis of tapentadol hydrochloride. |
| preparation | a green synthesis method of 3-methoxyphenylacetone. In order to solve the above technical problems, the present invention adopts the following technical solutions: adding magnesium powder and anhydrous aluminum trichloride into a reactor equipped with a reflux condenser and a dropping funnel, slowly add the mixed solution of M-methoxybromobenzene and tetrahydrofuran (THF) from the dropping funnel, and control the temperature of the reaction solution to 30-80 ℃ to keep the solution in a slightly boiling state, after completion of the dropwise addition, reflux was heated for 0.5-1.0h to ensure complete reaction of magnesium and obtain Grignard reagent. Propionitrile was slowly added dropwise to the Grignard reagent under stirring, and after the addition was completed, the reaction was continued for 1.0-2.0h. After completion of the reaction, 3mol/L hydrochloric acid was slowly added dropwise under a cold water bath to decompose the addition product and separate the inorganic phase. The organic phase was often subjected to pressure distillation to remove THF, and then subjected to vacuum distillation to obtain 3-methoxyphenylacetone. |
Last Update：2024-04-09 15:16:40
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